Epithelial-Mesenchymal Transition - an overview.
Epithelial to mesenchymal transition (EMT) is a process by which epithelial cells lose their orientation, cell to cell contacts and adopt the mobile characteristics of mesenchymal cells. EMT is not a change between two solid states but rather a process by which cells can move along a phenotypic spectrum (Figure 1). This is demonstrated by the existence of the reverse of EMT, mesenchymal to.
Epithelial to mesenchymal transition (EMT) is the process whereby epithelial cells are transformed into mesenchymal cells. Epithelial cells form the epithelium tissue which covers the internal and external body surface of an organism. These cells are polarized and form extensive cell-cell adhesions, including adherens junctions and tight junctions, with each other.
The epithelial mesenchymal transition (EMT) plays a central role in both normal physiological events (e.g., embryonic development) and abnormal pathological events (e.g., tumor formation and metastasis). The processes that occur in embryonic development are often reactivated under pathological conditions such as oncogenesis. Therefore, defining the regulatory networks (both gene and protein.
Epithelial-mesenchymal transition (EMT) is a physiological process in which epithelial cells acquire the motile and invasive characteristics of mesenchymal cells. Although EMT in embryonic development is a coordinated, organized process involving interaction between many different cells and tissue types, aspects of the EMT program can be inappropriately activated in response to.
Epithelial-to-mesenchymal transition (EMT) (synonym: epithelial-to-mesenchym conversion) describes a common process during morphogenesis and differentiation. It includes a series of coordinated events that result in cell-cell and cell-matrix interactions and cytoskeletal organization. EMT is a common event in early embryonic development, whereby tightly bound columnar (epithelial) cells lose.
Epithelial-mesenchymal transition (EMT) is a process whereby largely adherent and polarized epithelial cells acquire the phenotype of more mobile mesenchymal cells. EMT not only facilitates morphogenesis during embryonic development but also promotes invasion and metastasis in tumors. Pathological EMT is associated with E-cadherin repression, which has been shown to contribute to tumor.
Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This.